中文名 | (-)-INDOLACTAM V |
英文名 | (-)-INDOLACTAM V |
别名 | 吲哚内酰胺 V 化合物 T17299 |
英文别名 | (-)-Ilv Brn 4711877 (-)-INDOLACTAM V (2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl) 3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)- 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))- |
CAS | 90365-57-4 |
化学式 | C17H23N3O2 |
分子量 | 301.38 |
密度 | 1.166±0.06 g/cm3(Predicted) |
沸点 | 584.0±50.0 °C(Predicted) |
溶解度 | DMSO: >10mg/ml,澄清 |
酸度系数 | 14.39±0.10(Predicted) |
存储条件 | -20°C |
稳定性 | 从提供的购买之日起稳定1年。DMSO或乙醇中的溶液可以在-20 °C下储存长达2个月。 |
外观 | 白色粉末 |
体外研究 | (-)-Indolactam V is a PKC activator, with K i s of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity. (-)-Indolactam V shows K d s of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development. |
WGK Germany | 3 |
RTECS | UY8547000 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.318 ml | 16.59 ml | 33.181 ml |
5 mM | 0.664 ml | 3.318 ml | 6.636 ml |
10 mM | 0.332 ml | 1.659 ml | 3.318 ml |
5 mM | 0.066 ml | 0.332 ml | 0.664 ml |
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